Colgalt2^tm1.1Hwei
Targeted Allele Detail

Summary

• Symbol: Colgalt2^tm1.1Hwei
• Name: collagen beta(1-O)galactosyltransferase 2; targeted mutation 1.1, Hongshan Wei
• MGI ID: MGI:6763172
• Synonyms: Glt25d2^-
• Gene: Colgalt2 Location: Chr1:152275581-152386446 bp, + strand Genetic Position: Chr1, 64.77 cM
• Alliance: Colgalt2^tm1.1Hwei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked PGK-neo cassette replaced part of exon 2 and exon 3. A stop codon was added in frame into exon 2. The PGK-neo was removed via cre-mediated recombination in the ES cells. Western blot analysis confirmed absence of protein in lung, liver, spleen and brain. (J:310467, J:310468)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Colgalt2 Mutation: 54 strains or lines available

References

• Original: J:310468 Hao X, et al., Glt25d2 Knockout Directly Increases CD25+CD69- but Decreases CD25-CD69+ Subset Proliferation and is Involved in Concanavalin-Induced Hepatitis. Cell Physiol Biochem. 2018;50(3):1186-1200
• All: 3 reference(s)