Cdh23^em2Rmps
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdh23^em2Rmps
• Name: cadherin related 23 (otocadherin); endonuclease-mediated mutation 2, Lab. for Molecular Psychiatry, RIKEN Center for Brain Science
• MGI ID: MGI:6729239
• Synonyms: Cdh23 c.753G
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^em2Rmps page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting altered the coding sequence from A to G at coding nucleotide 753 (SNP rs257098870) in exon 7 to revert the Cdh23^ahl allele disrupting the splice donor site. (J:303657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 273 strains or lines available

References

• Original: J:303657 Balan S, et al., Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia. Schizophr Bull. 2021 Feb 17
• All: 1 reference(s)