Znrf3^tm1.1Npa
Targeted Allele Detail

Summary

• Symbol: Znrf3^tm1.1Npa
• Name: zinc and ring finger 3; targeted mutation 1.1, Novartis Pharma AG
• MGI ID: MGI:6724094
• Synonyms: Znrf3lox
• Gene: Znrf3 Location: Chr11:5226329-5394847 bp, - strand Genetic Position: Chr11, 3.46 cM
• Alliance: Znrf3^tm1.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236636
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 6 and a second loxP site into intron 7. The loxP sites are approximately 0.7 kb apart and flank RING domain coding exon 7. The FRT site flanked neomycin resistance gene cassette that was also inserted, was removed through subsequent flp-mediated recombination. (J:236636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znrf3 Mutation: 45 strains or lines available

References

• Original: J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79
• All: 1 reference(s)