Dock8^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Dock8^tm1.1Geno
• Name: dedicator of cytokinesis 8; targeted mutation 1.1, Genoway
• MGI ID: MGI:6716854
• Synonyms: Dock8^-
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 8 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 10. Floxed exons 9 and 10 were deleted through subsequent cre-mediated recombination. (J:306560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 101 strains or lines available

References

• Original: J:306560 Schneider C, et al., Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response. Nat Immunol. 2020 Dec;21(12):1528-1539
• All: 1 reference(s)