Gt(ROSA)26Sor^{tm3(TNFRSF11A*K240E)Jrld}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(TNFRSF11A*K240E)Jrld}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Jurgen Ruland
• MGI ID: MGI:6715558
• Synonyms: RANK^{K240E stopFL}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(TNFRSF11A*K240E)Jrld} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(TNFRSF11A*K240E)Jrld} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNFRSF11A (8792)

  Tnfrsf11a

  (MGI:1314891)

• Mutation details: Human TNFRSF11A cDNA containing a lysine to glutamate substitution at amino acid 240 (K240E), and IRES, and EGFP gene preceded by a loxP-flanked transcriptional and translational STOP cassette was inserted into the locus. (J:306127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:306127 Alankus B, et al., Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia. J Exp Med. 2021 Feb 1;218(2)
• All: 2 reference(s)