Dpysl2^em1Rkha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dpysl2^em1Rkha
• Name: dihydropyrimidinase-like 2; endonuclease-mediated mutation 1, Rajesh Khanna
• MGI ID: MGI:6712639
• Synonyms: CRMP2^K374A
• Gene: Dpysl2 Location: Chr14:67040313-67148410 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Dpysl2^em1Rkha page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR targeting converted the AAG to GCG resulting in the amino acid substitution of lysine with an alanine at position 374 (K374A). A silent mutation was inserted upstream of the altered codon to produce an Mspl restriction enzyme site. (J:305668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpysl2 Mutation: 34 strains or lines available

References

• Original: J:305668 Moutal A, et al., Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain. Pain. 2020 Nov;161(11):2629-2651
• All: 2 reference(s)