Rock1^tm1.1Bicrq
Targeted Allele Detail

Summary

• Symbol: Rock1^tm1.1Bicrq
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1.1, Cancer Research UK Beatson Institute
• MGI ID: MGI:6696418
• Synonyms: ROCK1 D1113A, ROCK1nc
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm1.1Bicrq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304720
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 27 was replaced with a floxed neomycin resistance cassette and a modified exon 27 with the amino acid substitution of aspartic acid with alanine at position 1113 (D1113A) to make the produced protein caspase-resistant. Cre-mediated recombination removed the selection cassette. (J:304720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 61 strains or lines available

References

• Original: J:304720 Julian L, et al., Defective apoptotic cell contractility provokes sterile inflammation leading to liver damage and tumour suppression. Elife. 2021 Apr 19;10:e61983
• All: 3 reference(s)