Cnot1^tm1.1Tya
Targeted Allele Detail

Summary

• Symbol: Cnot1^tm1.1Tya
• Name: CCR4-NOT transcription complex, subunit 1; targeted mutation 1.1, Tadashi Yamamoto
• MGI ID: MGI:6695738
• Synonyms: Cnot1 KO
• Gene: Cnot1 Location: Chr8:96446079-96534092 bp, - strand Genetic Position: Chr8, 47.18 cM
• Alliance: Cnot1^tm1.1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304612
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 21 and 22 were deleted after Cre-mediated recombination of flanking loxP sites in the germline. (J:304612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot1 Mutation: 159 strains or lines available

References

• Original: J:304612 Takahashi A, et al., The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Sci Alliance. 2020 May;3(5)
• All: 3 reference(s)