Fhip2b^em1Wwan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fhip2b^em1Wwan
• Name: FHF complex subunit HOOK interacting protein 2B; endonuclease-mediated mutation 1, Wen Wang
• MGI ID: MGI:6693525
• Synonyms: RAI16^-
• Gene: Fhip2b Location: Chr14:70820736-70837275 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Fhip2b^em1Wwan page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 37 bp deletion in exon 2. RT-PCR indicates that whole exon 2 is skipped in the mRNA. Western blot analysis shows no differences in protein level. (J:285283)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fhip2b Mutation: 28 strains or lines available

References

• Original: J:285283 Xu YL, et al., Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice. Cell Death Dis. 2019 Dec 20;10(12):958
• All: 2 reference(s)