Mertk^tm1.1Irb
Targeted Allele Detail

Summary

• Symbol: Mertk^tm1.1Irb
• Name: MER proto-oncogene tyrosine kinase; targeted mutation 1.1, Ira Tabas
• MGI ID: MGI:6690696
• Synonyms: Mertk^CR, MerTK^delta483-488
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^tm1.1Irb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234112
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: Codons 483-488 were deleted and a downstream Neo cassette (NeoR) flanked by LoxP sites was inserted. The neomycin selection cassette was removed via Cre-mediated recombination in the germline. (J:234112)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 66 strains or lines available

References

• Original: J:234112 Cai B, et al., MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6526-31
• All: 8 reference(s)