Mertk^tm1.1Cvro
Targeted Allele Detail

Summary

• Symbol: Mertk^tm1.1Cvro
• Name: MER proto-oncogene tyrosine kinase; targeted mutation 1.1, Carla Rothlin
• MGI ID: MGI:6690695
• Synonyms: Mertk^fl, Mertk^tm1.1Itl
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^tm1.1Cvro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269075
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exon 18. The frt-flanked neomycin selection cassette was removed via FLP1-mediated recombination in the germline. (J:269075)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 66 strains or lines available

References

• Original: J:269075 Fourgeaud L, et al., TAM receptors regulate multiple features of microglial physiology. Nature. 2016 Apr 14;532(7598):240-244
• All: 18 reference(s)