Rnf115^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf115^em1Gpt
• Name: ring finger protein 115; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6690637
• Synonyms: Rnf115^em1Cd
• Gene: Rnf115 Location: Chr3:96634869-96698471 bp, + strand Genetic Position: Chr3, 41.96 cM
• Alliance: Rnf115^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 removed about 500 bp resulting in a frame shift and premature termination. (J:297834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf115 Mutation: 37 strains or lines available

References

• Original: J:297834 Zhang ZD, et al., RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun. 2020 Nov 2;11(1):5536
• All: 1 reference(s)