Phenotypes associated with this allele

• Allele Symbol: Rnf115^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:6690637
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf115^em1Gpt/Rnf115^em1Gpt	C57BL/6JGpt-Rnf115^em1Gpt/Gpt	MGI:6690644

Genotype
MGI:6690644

hm1

• Allelic Composition: Rnf115^em1Gpt/Rnf115^em1Gpt
• Genetic Background: C57BL/6JGpt-Rnf115^em1Gpt/Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to viral infection induced morbidity/mortality ( J:297834 )

• in mice infected with EMCV

increased susceptibility to viral infection induced morbidity/mortality ( J:297834 )

• in mice infected with sub-lethal levels of HSV-1

immune system

increased circulating interferon-beta level ( J:297834 )

• in mice infected with EMCV

increased interferon-beta secretion ( J:297834 )

• from bone marrow-derived dendritic cells or mouse lung fibroblasts after SeV, VSV, or EMCV infection or transfection of poly(I:C)

increased susceptibility to viral infection induced morbidity/mortality ( J:297834 )

• in mice infected with sub-lethal levels of HSV-1

decreased susceptibility to viral infection ( J:297834 )

• increased interferon-beta secretion from bone marrow-derived dendritic cells or mouse lung fibroblasts after SeV, VSV, or EMCV infection or transfection of poly(I:C)

• mice infected with EMCV exhibit increased serum IFN-beta levels, reduced viral titer, and delayed onset of death compared with wild-type mice

decreased susceptibility to viral infection induced morbidity/mortality ( J:297834 )

• in mice infected with EMCV

homeostasis/metabolism

increased circulating interferon-beta level ( J:297834 )

• in mice infected with EMCV