Il1rn^tm1Snak
Targeted Allele Detail

Summary

• Symbol: Il1rn^tm1Snak
• Name: interleukin 1 receptor antagonist; targeted mutation 1, Susumu Nakae
• MGI ID: MGI:6690615
• Synonyms: Il1rn^gfp
• Gene: Il1rn Location: Chr2:24226872-24241503 bp, + strand Genetic Position: Chr2, 16.36 cM
• Alliance: Il1rn^tm1Snak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287341
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the sequence 3' to the start codon of exon 1 to a part of the intron 5' to exon 2 was replaced with a cassette consisting of IRES-EGFP and a neomycin resistance gene, flanked by loxP sequences. (J:287341)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1rn Mutation: 22 strains or lines available

Notes

BALB/c ES cells (SCC052, Merck)

References

• Original: J:287341 Yoshizaki T, et al., IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice. Sci Rep. 2019 Nov 19;9(1):17067
• All: 1 reference(s)