Gcgr^tm1.2Rdi
Targeted Allele Detail

Summary

• Symbol: Gcgr^tm1.2Rdi
• Name: glucagon receptor; targeted mutation 1.2, Richard DiMarchi
• MGI ID: MGI:6492461
• Synonyms: Gcgr KO
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^tm1.2Rdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4-10 were floxed, with a neomycin resistance gene and one loxP site inserted in the intron upstream of exon 4 and the other lox P site in the intron downstream of exon 10. Cre and Flp-mediated recombination removed the neomycin cassette and exons 4-10. (J:299380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 8 strains or lines available

References

• Original: J:299380 Rivero-Gutierrez B, et al., Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Mol Metab. 2018 Nov;17:28-38
• All: 1 reference(s)