Nfatc2tm1.1Ecan
Targeted Allele Detail
|
Symbol: |
Nfatc2tm1.1Ecan |
Name: |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; targeted mutation 1.1, Ernesto Canalis |
MGI ID: |
MGI:6469915 |
Synonyms: |
Nfatc2loxP |
Gene: |
Nfatc2 Location: Chr2:168318330-168443577 bp, - strand Genetic Position: Chr2, 88.91 cM
|
Alliance: |
Nfatc2tm1.1Ecan page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:289229
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
(129X1/SvJ x C57BL/6J)F1
|
|
Allele Type: |
|
Targeted (Conditional ready, No functional change) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A 5' loxP site was introduced approximately 0.4 kb 5' of exon 2, followed by the insertion of a FRT-flanked PGK promoter-driven neomycin selection cassette, and a 3' loxP site approximately 0.4 kb 3' of exon 2. Flp-mediated recombination removed the selection cassette leaving exon 2 floxed.
(J:289229)
|
|
|
|
Original: |
J:289229 Yu J, et al., Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo. J Cell Biochem. 2018 Nov;119(11):9334-9345 |
All: |
1 reference(s) |
|