Skp1^tm1.1Jw
Targeted Allele Detail

Summary

• Symbol: Skp1^tm1.1Jw
• Name: S-phase kinase-associated protein 1; targeted mutation 1.1, Jeremy Wang
• MGI ID: MGI:6455734
• Synonyms: Skp1^f
• Gene: Skp1 Location: Chr11:52122822-52137685 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Skp1^tm1.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289957
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed thymidine kinase selection cassette was inserted downstream of exon 5. Cre-mediated recombination removed the selection cassette and left exons 3 through 5 floxed. (J:289957)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Skp1 Mutation: 18 strains or lines available

References

• Original: J:289957 Guan Y, et al., SKP1 drives the prophase I to metaphase I transition during male meiosis. Sci Adv. 2020 Mar;6(13):eaaz2129
• All: 2 reference(s)