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Frem3em1Osb
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Frem3em1Osb
Name: Fras1 related extracellular matrix protein 3; endonuclease-mediated mutation 1, Institute for Microbial Diseases, Osaka University
MGI ID: MGI:6455416
Gene: Frem3  Location: Chr8:81337709-81421985 bp, + strand  Genetic Position: Chr8, 38.35 cM
Mutation
origin
Strain of Origin:  (C57BL/6NJcl x DBA/2NJcl)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-targeting of exon 1 (20 bp downstream of the translation initiation site) deleted 5 bp and produce a null allele. (J:291067)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Frem3 Mutation:  66 strains or lines available
References
Original:  J:291067 Kiyozumi D, et al., Genetic mutation of Frem3 does not causeFraser syndrome in mice. Exp Anim. 2020 Jan 29;69(1):104-109
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory