Rock1^tm2.1Leiw
Targeted Allele Detail

Summary

• Symbol: Rock1^tm2.1Leiw
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 2.1, Lei Wei
• MGI ID: MGI:6454673
• Synonyms: ROCK1^fl
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm2.1Leiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 5. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 5 floxed. (J:278809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 61 strains or lines available

References

• Original: J:278809 Shi J, et al., Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxcity. Oncotarget. 2018;9(16):12995-13008
• All: 4 reference(s)