Lepr^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lepr^em1Hwl
• Name: leptin receptor; endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6449242
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^em1Hwl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 5-bp deletion mutation in exon 3 was created by CRISPR/Cas9 genome editing technology. This causes a frameshift and introduces a premature stop codon. (J:280224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 123 strains or lines available

References

• Original: J:280224 Roh JI, et al., CRISPR-Cas9-mediated generation of obese and diabetic mouse models. Exp Anim. 2018 May 10;67(2):229-237
• All: 1 reference(s)