Ncoa1^tm1.1So
Targeted Allele Detail

Summary

• Symbol: Ncoa1^tm1.1So
• Name: nuclear receptor coactivator 1; targeted mutation 1.1, Steffi Oesterreich
• MGI ID: MGI:6442000
• Synonyms: NCOA1 P1278S SNP, SRC1^P1278S
• Gene: Ncoa1 Location: Chr12:4297362-4527182 bp, - strand Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
• Alliance: Ncoa1^tm1.1So page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct is designed to insert a loxP site downstream of exon 14 and an FRT-flanked neomycin (neo) resistance cassette, followed by a second loxP site downstream of exon 16. A CCA to TCA mutation was introduced in exon 16, encoding activation domain 2, converting a proline to a serine (P1278S) similar to a mutation found in a small cohort of bone metastases from breast cancer patients. Flp-mediated recombination removed the FRT-flanked neomycin cassette. (J:341575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncoa1 Mutation: 168 strains or lines available

References

• Original: J:341575 Watters RJ, et al., A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis. Endocrinology. 2021 Aug 1;162(8)
• All: 1 reference(s)