Hdac4^em1Hcu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdac4^em1Hcu
• Name: histone deacetylase 4; endonuclease-mediated mutation 1, Huxing Cui
• MGI ID: MGI:6441050
• Synonyms: Hdac4^A778T
• Gene: Hdac4 Location: Chr1:91856501-92123421 bp, - strand Genetic Position: Chr1, 46.24 cM
• Alliance: Hdac4^em1Hcu page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a single nucleotide change of G to A, resulting in an alanine to threonine change at amino acid 778 (p.A778T). This corresponds to the human A786T mutation associated with an increased risk of developing an eating disorder. (J:280111)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac4 Mutation: 110 strains or lines available

References

• Original: J:280111 Lutter M, et al., The Eating-Disorder Associated HDAC4(A778T) Mutation Alters Feeding Behaviors in Female Mice. Biol Psychiatry. 2017 May 1;81(9):770-777
• All: 2 reference(s)