Il22ra2^{tm2b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Il22ra2^{tm2b(EUCOMM)Wtsi}
• Name: interleukin 22 receptor, alpha 2; targeted mutation 2b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6423179
• Synonyms: Il22ra2 null lacZ
• Gene: Il22ra2 Location: Chr10:19497776-19510429 bp, + strand Genetic Position: Chr10, 8.52 cM
• Alliance: Il22ra2^{tm2b(EUCOMM)Wtsi} page
• IMPC: Il22ra2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287424
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 19501914 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 19502815. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm2a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:287424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il22ra2 Mutation: 22 strains or lines available

References

• Original: J:287424 Fachi JL, et al., Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. J Exp Med. 2020 Mar 2;217(3)
• All: 1 reference(s)