Ambn^tm1.1Jpsi
Targeted Allele Detail

Summary

• Symbol: Ambn^tm1.1Jpsi
• Name: ameloblastin; targeted mutation 1.1, James P Simmer
• MGI ID: MGI:6401827
• Synonyms: Ambn^lacZ
• Gene: Ambn Location: Chr5:88603850-88616390 bp, + strand Genetic Position: Chr5, 43.63 cM
• Alliance: Ambn^tm1.1Jpsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286128
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4,204 bp segment from the 5' end of the gene was replaced with an NLSlacZ inserted at the evolutionarily invariant strong translation initiation codon in exon 2. (J:286128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ambn Mutation: 32 strains or lines available

References

• Original: J:286128 Liang T, et al., AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout-NLS-lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue-specificity. Mol Genet Genomic Med. 2019 Sep;7(9):e929
• All: 1 reference(s)