Zdhhc1^tm1Yyiw
Targeted Allele Detail

Summary

• Symbol: Zdhhc1^tm1Yyiw
• Name: zinc finger, DHHC domain containing 1; targeted mutation 1, Yan-Yi Wang
• MGI ID: MGI:6393261
• Synonyms: Zdhhc1^-
• Gene: Zdhhc1 Location: Chr8:106199055-106223534 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Zdhhc1^tm1Yyiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284987
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon of the gene was replaced with a neomycin cassette, resulting in a frame-shift mutation and loss of protein expression from this locus. (J:284987)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc1 Mutation: 29 strains or lines available

References

• Original: J:284987 Zhou Q, et al., The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 2014 Oct 8;16(4):450-61
• All: 1 reference(s)