Phenotypes associated with this allele

• Allele Symbol: Zdhhc1^tm1Yyiw
• Allele Name: targeted mutation 1, Yan-Yi Wang
• Allele ID: MGI:6393261
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc1^tm1Yyiw/Zdhhc1^tm1Yyiw	involves: 129S6/SvEvTac	MGI:6458896

Genotype
MGI:6458896

hm1

• Allelic Composition: Zdhhc1^tm1Yyiw/Zdhhc1^tm1Yyiw
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:284987 )

• after intraperitoneal (i.p.) infection with herpes simplex virus-1 (HSV-1) at a high dose (5 x 10⁷ pfu/mouse), 8-week-old mice show a significantly higher susceptibility to HSV-1-triggered death than wild-type controls, with all mice found dead within 9 days post-infection

immune system

immune system phenotype ( J:284987 )

N • uninfected mice show no significant changes in the numbers or compositions of major immune cells in lymph nodes, spleen, and thymus relative to wild-type controls

N • after i.p. infection with vesicular stomatitis virus (VSV) at a high dose (2 x 10⁷ pfu/mouse), mice show no significant differences in survival relative to similarly infected wild-type controls

abnormal circulating cytokine level ( J:284987 )

• at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse, 8-week-old mice show significantly reduced serum cytokine levels relative to similarly infected wild-type controls

• however, mice show normal serum cytokine levels after i.p. infection with VSV at 1 x 10⁷ pfu/mouse

decreased circulating interferon-alpha level ( J:284987 )

• significant reduction in serum IFN-alpha levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating interferon-beta level ( J:284987 )

• significant reduction in serum IFN-beta levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating interleukin-6 level ( J:284987 )

• significant reduction in serum IL-6 levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating tumor necrosis factor level ( J:284987 )

• significant reduction in serum TNFalpha levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

increased susceptibility to Herpesvirales infection ( J:284987 )

• 6 days after intranasal (i.n.) infection with HSV-1 at 1 x 10⁶ pfu/mouse, mice exhibit significantly higher viral titers in the brain along with markedly reduced mRNA levels of downstream effecter genes relative to similarly infected wild-type controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:284987 )

• after intraperitoneal (i.p.) infection with herpes simplex virus-1 (HSV-1) at a high dose (5 x 10⁷ pfu/mouse), 8-week-old mice show a significantly higher susceptibility to HSV-1-triggered death than wild-type controls, with all mice found dead within 9 days post-infection

homeostasis/metabolism

abnormal circulating cytokine level ( J:284987 )

• at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse, 8-week-old mice show significantly reduced serum cytokine levels relative to similarly infected wild-type controls

• however, mice show normal serum cytokine levels after i.p. infection with VSV at 1 x 10⁷ pfu/mouse

decreased circulating interferon-alpha level ( J:284987 )

• significant reduction in serum IFN-alpha levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating interferon-beta level ( J:284987 )

• significant reduction in serum IFN-beta levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating interleukin-6 level ( J:284987 )

• significant reduction in serum IL-6 levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse

decreased circulating tumor necrosis factor level ( J:284987 )

• significant reduction in serum TNFalpha levels at 6 h after i.p. infection with HSV-1 at 1 x 10⁷ pfu/mouse