Ngf^tm1(NGF*)Cat
Targeted Allele Detail

Summary

• Symbol: Ngf^tm1(NGF*)Cat
• Name: nerve growth factor; targeted mutation 1, Antonio Cattaneo
• MGI ID: MGI:6388456
• Synonyms: NGF^R100W
• Gene: Ngf Location: Chr3:102377235-102428329 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Ngf^tm1(NGF*)Cat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282017
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Ngf^tm1(NGF*)Cat expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NGF (4803)

  Ngf	(MGI:97321)

  Contains R100W mutation

• Mutation details: The human NGF coding sequence with an arginine to tryptophan substitution at amino acid 100 (R100W) and loxP flanked NeoR/KanR cassette and PGK promoter replaced the mouse Ngf coding sequence via homologous recombination. The C to T transition at position 661 resulting in the R100W mutation is seen in patients with Hereditary Sensory and Autonomic Neuropathy type 5. (J:282017)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngf Mutation: 12 strains or lines available

References

• Original: J:282017 Testa G, et al., The NGF(R100W) Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V. J Neurosci. 2019 Dec 4;39(49):9702-9715
• All: 2 reference(s)