Phenotypes associated with this allele

• Allele Symbol: Ngf^tm1(NGF*)Cat
• Allele Name: targeted mutation 1, Antonio Cattaneo
• Allele ID: MGI:6388456
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ngf^tm1(NGF*)Cat/Ngf^tm1(NGF*)Cat	involves: 129S1/Sv * 129X1/SvJ	MGI:6388457
ht2	Ngf^tm1(NGF*)Cat/Ngf^+	involves: 129S1/Sv * 129X1/SvJ	MGI:6388458

Genotype
MGI:6388457

hm1

• Allelic Composition: Ngf^tm1(NGF*)Cat/Ngf^tm1(NGF*)Cat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:282017 , J:284096 )

• mice die by P30 (J:282017)

• mice die by the first month of life (J:284096)

• treatment of pregnant dams and pups with mouse NGF (from beginning of gestation until 10 days post-delivery followed by intranasal and subcutaneous NGF administration to pups) fully rescues the early lethality (J:284096)

growth/size/body

decreased body weight ( J:284096 )

• body weight at P15, but not at birth, is lower

• administration of mouse NGF restores body weight for the first 2 weeks

nervous system

abnormal striatum morphology ( J:284096 )

• density of ChAT+ neurons in the striatum is increased

abnormal cholinergic neuron morphology ( J:284096 )

• density of ChAT+ neurons in the striatum is increased

• however, density of ChAT+ neurons in the basal forebrain (medial septum and nucleus basalis of Meynert) are unchanged

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory and autonomic neuropathy type 5		DOID:0070145	OMIM:608654	J:284096

Genotype
MGI:6388458

ht2

• Allelic Composition: Ngf^tm1(NGF*)Cat/Ngf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

behavior/neurological phenotype ( J:282017 )

N • mice show no learning or memory deficits in the Morris water maze, in the object recognition test, in exploratory activity and preference index

abnormal touch/ nociception ( J:282017 )

• however, response to gentle stroking of the glabrous skin is normal

• a non-noxious stimulus (small piece of tape applied to the back) takes more time to induce a removal reaction than in controls at 6 months of age, but not at 2 months, indicating that mice are less sensitive to somatosensory inputs

increased chemical nociceptive threshold ( J:282017 )

• chemical nociception induced by capsaicin injection in the hindpaw is impaired at 2 months and 6 months of age

increased thermal nociceptive threshold ( J:282017 )

• thermal nociception is normal at 2 month of age but decreases by 6 months of age, with adults showing a higher latency to respond to high-temperature stimulus

• cold sensitivity, measured by topical acetone application on the hindpaw, is reduced at 2 and 6 months of age

nervous system

nervous system phenotype ( J:282017 )

N • mice show normal numbers of DRG neurons at P5, 2 months, and 6 months, normal numbers of SCG, normal density of ChAT+ neurons in the medial septum and striatum, normal conduction velocities of the 3 main sensory fiber populations, ABeta, Adelta, and C fibers, and normal Schaffer collateral-CA1 long-term potentiation

abnormal sensory neuron innervation pattern ( J:282017 )

• mice show a reduction in hairy and glabrous (sensory fibers) skin sensory innervation at 6 months of age, but not at 2 months

• however, mice show normal sympathetic innervation of key target organs such as the heart, stomach, kidney, spleen

abnormal sciatic nerve morphology ( J:282017 )

• cross-sectional area of the sciatic nerve is decreased

• sciatic nerve shows a decrease in the number of nonmyelinated axons

• however, the number of myelinated axons in the sciatic nerve is unaffected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory and autonomic neuropathy type 5		DOID:0070145	OMIM:608654	J:282017