Vegfc^tm1.2Mlkn
Targeted Allele Detail

Summary

• Symbol: Vegfc^tm1.2Mlkn
• Name: vascular endothelial growth factor C; targeted mutation 1.2, Mark L Kahn
• MGI ID: MGI:6385696
• Synonyms: Vegfc^RC
• Gene: Vegfc Location: Chr8:54530567-54639489 bp, + strand Genetic Position: Chr8, 29.2 cM, cytoband B3
• Alliance: Vegfc^tm1.2Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282014
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites and a FRT-flanked neomycin resistance cassette was inserted upstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exon 3 in the germline. (J:282014)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vegfc Mutation: 27 strains or lines available

References

• Original: J:282014 Lim L, et al., Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC. Blood. 2019 Nov 14;134(20):1764-1775
• All: 1 reference(s)