Dpysl2^{tm2c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Dpysl2^{tm2c(KOMP)Wtsi}
• Name: dihydropyrimidinase-like 2; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6379581
• Synonyms: CRMP2^f
• Gene: Dpysl2 Location: Chr14:67040313-67148410 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Dpysl2^{tm2c(KOMP)Wtsi} page

Mutation origin

• Mutant Cell Line: EPD0110_2_G07
• Germline Transmission: Earliest citation of germline transmission: J:281628
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at a position on Chromosome 14 upstream of exon 3 of the gene. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the FRT-flanked lacZ and neo cassette leaving exon 3 floxed. (J:281628)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpysl2 Mutation: 34 strains or lines available

References

• Original: J:281628 Moutal A, et al., Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis. ASN Neuro. 2019 Jan-Dec;11:1759091419892090
• All: 1 reference(s)