Mip^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Mip^tm1.1Itl
• Name: major intrinsic protein of lens fiber; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:6367813
• Synonyms: AQP0^deltaC
• Gene: Mip Location: Chr10:128061707-128067681 bp, + strand Genetic Position: Chr10, 76.49 cM, cytoband D1
• Alliance: Mip^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272334
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A stop codon was introduced after codon 246, predicted to result in the expression of a truncated protein that lacks amino acids 247-263. An adjacent frt-flanked neomycin selection cassette was removed via Flp-mediated recombination in the germline. (J:272334)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mip Mutation: 31 strains or lines available

References

• Original: J:272334 Varadaraj K, et al., Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0DeltaC/DeltaC Mice. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):858-867
• All: 3 reference(s)