Rag2^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag2^em1Hwl
• Name: recombination activating gene 2; endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6363058
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^em1Hwl page

Mutation origin

• Strain of Origin: FVB/NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of 22 base pairs in exon 3, which created a frameshift mutation and a premature stop codon. (J:265348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 117 strains or lines available

References

• Original: J:265348 Lee JH, et al., Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout. Transgenic Res. 2018 Jun;27(3):241-251
• All: 2 reference(s)