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Targeted Allele Detail
Symbol: Mir146tm1.1Lfl
Name: microRNA 146; targeted mutation 1.1, Li-Fan Lu
MGI ID: MGI:6359885
Synonyms: miR-146afl
Gene: Mir146  Location: Chr11:43374397-43374461 bp, - strand  Genetic Position: Chr11, 25.68 cM
Germline Transmission:  Earliest citation of germline transmission: J:266124
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a loxP site and a single loxP site flank the microRNA sequence. Flp-mediated recombination removed the selection cassette and left the microRNA sequence floxed. (J:266124)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir146 Mutation:  7 strains or lines available
Original:  J:266124 Cho S, et al., Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018 Jul 16;9(1):2757
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory