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Zc3h12ctm2c(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Zc3h12ctm2c(EUCOMM)Hmgu
Name: zinc finger CCCH type containing 12C; targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:6359731
Synonyms: Regnase-3fl
Gene: Zc3h12c  Location: Chr9:52111344-52168572 bp, - strand  Genetic Position: Chr9, 28.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277714
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 52120843 of Chromosome 9 upstream of the critical exon 4 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 52119928. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:277714)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zc3h12c Mutation:  25 strains or lines available
References
Original:  J:277714 von Gamm M, et al., Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 Jul 1;216(7):1700-1723
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory