Mpzl2^tm1.1Jczp
Targeted Allele Detail

Summary

• Symbol: Mpzl2^tm1.1Jczp
• Name: myelin protein zero-like 2; targeted mutation 1.1, Juan Carlos Zuniga-Pflucker
• MGI ID: MGI:6358214
• Synonyms: Eva1^ko
• Gene: Mpzl2 Location: Chr9:44951595-44965341 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Mpzl2^tm1.1Jczp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267880
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targetting constract inseted two loxP sites flanking exons 2 and 3 of Mpz12 gene encoding for the extracellular portion of the protein. Mice are then crossed with cre deleter to remove exons 2 and 3. This allele is a null allele, however RT-PCR on liver RNA confirmed transcript splicing of exon 1 to exon 4 was detectable in the mutant mice (J:267871). The presence of the shortened protein in tisses of has not been tetermined. (J:267880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpzl2 Mutation: 18 strains or lines available

References

• Original: J:267880 Garabatos N, et al., A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes. Monoclon Antib Immunodiagn Immunother. 2014 Oct;33(5):305-11
• All: 2 reference(s)