Kcnj8^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Kcnj8^tm1.2Geno
• Name: potassium inwardly-rectifying channel, subfamily J, member 8; targeted mutation 1.2, Genoway
• MGI ID: MGI:6358101
• Synonyms: Kir6.1^-
• Gene: Kcnj8 Location: Chr6:142510563-142517340 bp, - strand Genetic Position: Chr6, 74.31 cM
• Alliance: Kcnj8^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277504
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site together with an frt-flanked neomycin selection cassette was inserted in intron 1. Exon 2 contains the ATG translation initiation codon. A second loxP site was inserted distal to exon 2 in intron 2. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. Subsequent Cre-mediated recombination in the germline resulted in the deletion of the loxP-flanked sequences including exon 2. (J:277504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kcnj8 Mutation: 32 strains or lines available

References

• Original: J:277504 Aziz Q, et al., The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension. 2014 Sep;64(3):523-9
• All: 4 reference(s)