Amfr^tm1.1Blsg
Targeted Allele Detail

Summary

• Symbol: Amfr^tm1.1Blsg
• Name: autocrine motility factor receptor; targeted mutation 1.1, Bao-Liang Song
• MGI ID: MGI:6358039
• Synonyms: gp78^fl
• Gene: Amfr Location: Chr8:94698216-94739301 bp, - strand Genetic Position: Chr8, 45.96 cM
• Alliance: Amfr^tm1.1Blsg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the introns flanking exon 5 and 8, along with a neo cassette (G418 resistance) surrounded by FRT sites as a selectable marker. The neo cassette was removed via FLP-mediated recombination. (J:270119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amfr Mutation: 44 strains or lines available

References

• Original: J:270119 Liu TF, et al., Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metab. 2012 Aug 8;16(2):213-25
• All: 5 reference(s)