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Targeted Allele Detail
Symbol: Stk38ltm1b(KOMP)Wtsi
Name: serine/threonine kinase 38 like; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:6356401
Gene: Stk38l  Location: Chr6:146724995-146778812 bp, + strand  Genetic Position: Chr6, 77.7 cM
Mutant Cell Line:  EPD0396_5_A05
Germline Transmission:  Earliest citation of germline transmission: J:265036
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 146767966 of Chromosome 6 upstream of the critical exon 7 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 7 at position 146768577. The critical exon 7 is thus flanked by loxP sites. The lacZ open reading frame is not in frame with exon 6 and not expected to produce a reporter protein (confirmed by immunoblotting). Cre expression without flp expression generated a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:265036)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk38l Mutation:  27 strains or lines available
Original:  J:265036 Leger H, et al., Ndr kinases regulate retinal interneuron proliferation and homeostasis. Sci Rep. 2018 Aug 22;8(1):12544
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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