Hrc^tm1Choc
Targeted Allele Detail

Summary

• Symbol: Hrc^tm1Choc
• Name: histidine rich calcium binding protein; targeted mutation 1, Chunghee Cho
• MGI ID: MGI:6355970
• Gene: Hrc Location: Chr7:44984714-44988398 bp, + strand Genetic Position: Chr7, 29.26 cM
• Alliance: Hrc^tm1Choc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275091
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette. Reverse transcription PCR (RT-PCR) analysis demonstrated the lack of expresed transcript (mRNA) in heart tissue derived from homozygous mice. (J:275091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrc Mutation: 44 strains or lines available

References

• Original: J:275091 Park CS, et al., Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Res Cardiol. 2013 May;108(3):344
• All: 2 reference(s)