Idh3a^em1Jkn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Idh3a^em1Jkn
• Name: isocitrate dehydrogenase 3 (NAD+) alpha; endonuclease-mediated mutation 1, Ian J Jackson
• MGI ID: MGI:6355402
• Gene: Idh3a Location: Chr9:54493795-54511946 bp, + strand Genetic Position: Chr9, 29.7 cM
• Alliance: Idh3a^em1Jkn page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• The molecular lesion is a 5bp insertion mutation, c.702_703InsGTACT. (J:267900)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Idh3a Mutation: 21 strains or lines available

References

• Original: J:267900 Findlay AS, et al., Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Dis Model Mech. 2018 Dec 18;11(12):dmm036426
• All: 2 reference(s)