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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Idh3aem1Jkn
endonuclease-mediated mutation 1, Ian J Jackson
MGI:6355402
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Idh3aem1Jkn/Idh3aem1Jkn involves: C57BL/6J MGI:6358218
ht2
 		Idh3ampc201H/Idh3aem1Jkn involves: C57BL/6J MGI:6358221


Genotype
MGI:6358218
hm1
Allelic
Composition		 Idh3aem1Jkn/Idh3aem1Jkn
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh3aem1Jkn mutation (0 available); any Idh3a mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:267900 )
• no embryos found at E10.5 and E12.5 and only the remains of developmentally delayed embryos at E8.5




Genotype
MGI:6358221
ht2
Allelic
Composition		 Idh3ampc201H/Idh3aem1Jkn
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh3aem1Jkn mutation (0 available); any Idh3a mutation (21 available)
Idh3ampc201H mutation (0 available); any Idh3a mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
increased susceptibility to age-related retinal degeneration ( J:267900 )
• loss of significant portion of nuclei in outer nuclear layer (ONL) at age P60, progressing further by P90
• significantly reduced a-wave response and flatline ERG trace at age P60
• normal retinal function at age P30 as determined by electroretinograms (ERGs)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory