Apmap^tm1.1Jgbs
Targeted Allele Detail

Summary

• Symbol: Apmap^tm1.1Jgbs
• Name: adipocyte plasma membrane associated protein; targeted mutation 1.1, Juliane Bogner-Strauss
• MGI ID: MGI:6343492
• Gene: Apmap Location: Chr2:150425000-150450487 bp, - strand Genetic Position: Chr2, 74.68 cM
• Alliance: Apmap^tm1.1Jgbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247647
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 (containing the ATG start codon), and a loxP flanked neomycin cassette was inserted downstream of exon 1. The neomycin selection cassette was removed in ES cells via Cre-mediated recombination. (J:247647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apmap Mutation: 21 strains or lines available

References

• Original: J:247647 Pessentheiner AR, et al., APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion. FASEB J. 2017 Sep;31(9):4088-4103
• All: 1 reference(s)