Mirc11^tm1.1Wtsi
Targeted Allele Detail

Summary

• Symbol: Mirc11^tm1.1Wtsi
• Name: microRNA cluster 11, including Mir23a through Mir24-2; targeted mutation 1.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6342207
• Gene: Mirc11 Location: Chr8:84935147-84935550 bp Genetic Position: Chr8, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258947
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: Sanger miRNA knockouts

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Mir23a, Mir27a, Mir3074-2, and Mir24-2 in this microRNA cluster were replaced via homologous recombination by a puromycin/thymidine kinase fusion gene under the control of EM7/PGK promoters and flanked by LoxP and F3/FRT sites. The selection cassette was removed via cre-mediated recombination. (J:258947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc11 Mutation: 2 strains or lines available

References

• Original: J:258947 Pua HH, et al., MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19;44(4):821-32
• All: 1 reference(s)