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Gas2l2tm1c(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Gas2l2tm1c(KOMP)Wtsi
Name: growth arrest-specific 2 like 2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6336196
Synonyms: Gas2l2fl
Gene: Gas2l2  Location: Chr11:83421902-83429455 bp, - strand  Genetic Position: Chr11, 50.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277289
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 83427938 of Chromosome 11 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 83426973. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was then created by flp recombinase expression in mice carrying this allele. (J:277289)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gas2l2 Mutation:  20 strains or lines available
References
Original:  J:277289 Bustamante-Marin XM, et al., Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance. Am J Hum Genet. 2019 Feb 7;104(2):229-245
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory