Rr75tm1.1Tyag
Targeted Allele Detail
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Symbol: |
Rr75tm1.1Tyag |
Name: |
regulatory region 75; targeted mutation 1.1, Takeshi Yagi |
MGI ID: |
MGI:6336179 |
Synonyms: |
deltaHS19-20 |
Gene: |
Rr75 Location: unknown Genetic Position: Chr18, Syntenic
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Alliance: |
Rr75tm1.1Tyag page
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Germline Transmission: |
Earliest citation of germline transmission:
J:277249
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Hypomorph, Modified regulatory region) |
Mutation: |
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Intergenic deletion
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Mutation details: Mouse BAC RP23-336G22 was used as the basis of the targeting vector. A loxP site was inserted downstream of the sequence containing DNase1 hypersensitivity regions HS19 and HS20 (HS19-20). A loxP and frt site flanked neomycin resistance gene cassette was inserted upstream. The floxed regulatory region sequence and neo cassette were deleted through subsequent cre-mediated recombination. The regulatory regions are located downstream of the Pcdhg cluster (and upstream of the neighboring Diaph1 gene on the reverse strand). Mice with this deletion allele show an average reduction of around 50% in expression of Pcdhb cluster genes. The Pcdhb cluster is located upstream of the Pcdhg cluster and this allele is located around 360kb downstream of the distal-most gene in the Pcdhb cluster.
(J:277249)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr75 Mutation: |
0 strains or lines available
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Original: |
J:277249 Yokota S, et al., Identification of the cluster control region for the protocadherin-beta genes located beyond the protocadherin-gamma cluster. J Biol Chem. 2011 Sep 9;286(36):31885-95 |
All: |
1 reference(s) |
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