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Rr75tm1.1Tyag
Targeted Allele Detail
Summary
Symbol: Rr75tm1.1Tyag
Name: regulatory region 75; targeted mutation 1.1, Takeshi Yagi
MGI ID: MGI:6336179
Synonyms: deltaHS19-20
Gene: Rr75  Location: unknown  Genetic Position: Chr18, Syntenic
Alliance: Rr75tm1.1Tyag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277249
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified regulatory region)
Mutation:    Intergenic deletion
 
Mutation detailsMouse BAC RP23-336G22 was used as the basis of the targeting vector. A loxP site was inserted downstream of the sequence containing DNase1 hypersensitivity regions HS19 and HS20 (HS19-20). A loxP and frt site flanked neomycin resistance gene cassette was inserted upstream. The floxed regulatory region sequence and neo cassette were deleted through subsequent cre-mediated recombination. The regulatory regions are located downstream of the Pcdhg cluster (and upstream of the neighboring Diaph1 gene on the reverse strand). Mice with this deletion allele show an average reduction of around 50% in expression of Pcdhb cluster genes. The Pcdhb cluster is located upstream of the Pcdhg cluster and this allele is located around 360kb downstream of the distal-most gene in the Pcdhb cluster. (J:277249)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr75 Mutation:  0 strains or lines available
References
Original:  J:277249 Yokota S, et al., Identification of the cluster control region for the protocadherin-beta genes located beyond the protocadherin-gamma cluster. J Biol Chem. 2011 Sep 9;286(36):31885-95
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory