Igh^tm10.1Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm10.1Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 10.1, Michel Cogne
• MGI ID: MGI:6317347
• Synonyms: Delta2-3''RR, deltaleftPAL, Rr152^tm10.1Cog
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234741
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Igh 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 (Rr153) flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a (Rr154) and hs3b (Rr155)). Enhancer hs4 (Rr156) lies downstream of the palindrome. This allele has a deletion of the left part of the 3'RR (hs3a-IRIS-hs1,2). (J:234741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:234741 Saintamand A, et al., Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730
• All: 2 reference(s)