Ightm9.1Cog
Targeted Allele Detail
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Symbol: |
Ightm9.1Cog |
Name: |
immunoglobulin heavy chain complex; targeted mutation 9.1 Michel Cogne |
MGI ID: |
MGI:6317346 |
Synonyms: |
deltaIRIS, Rr152tm9.1Cog |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:234741
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Modified regulatory region) |
Mutation: |
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Intergenic deletion
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Mutation details: The Igh 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 (Rr153) flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a (Rr154) and hs3b (Rr155)). Enhancer hs4 (Rr156) lies downstream of the palindrome. This allele fully eliminates the left-side IRIS while maintaining all four core enhancer elements.
(J:234741)
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Original: |
J:234741 Saintamand A, et al., Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730 |
All: |
1 reference(s) |
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