Tdo2^tm1.1Dkfz
Targeted Allele Detail

Summary

• Symbol: Tdo2^tm1.1Dkfz
• Name: tryptophan 2,3-dioxygenase; targeted mutation 1.1, German Cancer Research Center
• MGI ID: MGI:6306653
• Synonyms: reporter-TDO, Tdo2tm#(GFP/Luc)/Dkfz
• Gene: Tdo2 Location: Chr3:81865719-81883035 bp, - strand Genetic Position: Chr3, 35.97 cM
• Alliance: Tdo2^tm1.1Dkfz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275089
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A copGFP and a firefly luciferase gene were inserted into the gene, starting at the start codon. An frt-flanked neomycin selection cassette was inserted following the reporter genes. A stop codon was inserted at the 5' end of the inserted construct. The neomycin selection cassette was remove via FLP-mediated recombination. (J:275089)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdo2 Mutation: 37 strains or lines available

References

• Original: J:275089 Lanz TV, et al., Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis. Sci Rep. 2017 Jan 24;7:41271
• All: 1 reference(s)