Prkcb^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkcb^M5Btlr
• Name: protein kinase C, beta; mutation 5, Bruce Beutler
• MGI ID: MGI:6305128
• Synonyms: Tikrit
• Gene: Prkcb Location: Chr7:121888327-122233625 bp, + strand Genetic Position: Chr7, 65.75 cM
• Alliance: Prkcb^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 122,627,693 (v38) on chromosome 7, or base pair 338,569 in the GenBank genomic region NC_000073. The mutation corresponds to residue 2,121 in the mRNA sequence NM_008855 within exon 17 of 17 total exons. The mutation results in a threonine to isoleucine substitution at position 634 (T634I) in the PKC protein. (J:274861)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcb Mutation: 37 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4265

References

• Original: J:274861 Choi JH, et al., Mutagenetix entry for Tikrit. MGI Direct Data Submission. 2019
• All: 1 reference(s)