Atp6v0a2^tm1Kdb
Targeted Allele Detail

Summary

• Symbol: Atp6v0a2^tm1Kdb
• Name: ATPase, H+ transporting, lysosomal V0 subunit A2; targeted mutation 1, Kenneth D Beaman
• MGI ID: MGI:6303630
• Synonyms: a2V^f, a2V^fl
• Gene: Atp6v0a2 Location: Chr5:124767117-124801519 bp, + strand Genetic Position: Chr5, 63.7 cM
• Alliance: Atp6v0a2^tm1Kdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-FRT flanked neo cassette was introduced upstream of exon 12 and a third loxP was inserted downstream of exon 14. (J:274047)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6v0a2 Mutation: 52 strains or lines available

References

• Original: J:274047 Pamarthy S, et al., The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-beta signaling. Cell Death Dis. 2016 Nov 3;7(11):e2443
• All: 3 reference(s)